Waldenstroms Macroglobulinemia
Waldenstroms Macroglobulinemia Symptoms

Symptoms Of Waldenstroms Macroglobulinemia

In the early stages of the disease, after waldenstrom's macroglobulinemia diagnosis, the symptoms are few and far between. The majority of symptoms do not appear in patients until the disease is at a fairly advanced stage and even then the symptoms can vary hugely between patients. Many of the symptoms of waldenstrom's macroglobulinemia are identical to the symptoms of patients diagnosed with other types of non-Hodgkin lymphomas. These can include weakness and fatigue, fever, swollen lymph-nodes and weight loss.

However, other waldenstrom's macroglobulinemia symptoms occur because of the overproduction of Igm which can cause hyper-viscosity in the blood which causes problems with circulation and the nervous system. If the circulation is reduced to the brain, problems are similar to a shake can occur.

This problem with circulation can lead some patients with waldenstrom's macroglobulinemia to experience Raynaud's phenomenon which can cause blood vessels to tighten slowing the blood. This can cause circulation to be cut off to certain parts of the patient's body, primarily their hands and feet. Not all patients with waldenstrom's macroglobulinemia suffer with hyper-viscosity or Raynaud's phenomenon.

Waldenstroms Macroglobulinemia Symptoms

The main symptoms of waldenstrom's macroglobulinemia include:

  • Weakness and fatigue; this is the most common symptom and can be caused by lymphoma cells crowding out red blood cells within bone marrow.
  • Enlarged lymph-nodes and a swollen abdomen caused by an enlarged spleen or liver.
  • Loss of appetite which appears in about a quarter of waldenstrom's macroglobulinemia patients and can be caused by the spleen pressing on the stomach, which in turn can cause weight loss.
  • Nervous system problems which most commonly occurs as a tingling or numbing in hands and feet but can also manifest itself as slurred speech, dizziness and confusion.
  • Easy bruising.
  • Abnormal bleeding caused by damaged blood vessels.
  • Waldenstrom's macroglobulinemia can cause retinal bleeding which may cause blurred vision or blind spots.
  • Waldenstrom's macroglobulinemia can also cause damage to the heart and kidneys in its advanced stage.